Judy S. (Lobsinger) Crabtree Ph.D.
Morgantown, Pa.
Phone
e-mail

Academic Training:
1992 B.S. in Chemistry University of Oklahoma
1994 M.S. in Biochemistry University of Oklahoma
1997 Ph.D. in Biochemistry University of Oklahoma

Professional Experience:
1987-1992 Undergraduate Research Assistant, The University of Oklahoma (Advisor: Bruce A. Roe)
1992-1997 Graduate Research Fellow, The University of Oklahoma (Advisor: Bruce A. Roe)
1997-2001 IRTA Postdoctoral Fellow, National Human Genome Research Institute, National Institutes of Health (Advisor: Francis S. Collins)
2001-present Research Fellow, National Human Genome Research Institute,
National Institutes of Health (Advisor: Francis S. Collins)

Honors and Affiliations:
1991 Phi Lambda Upsilon Outstanding Undergraduate Research Student,
The University of Oklahoma
1992-1997 Department of Education Graduate Research Fellow Grant
1992-present Member Phi Lambda Upsilon
1998-present Member American Association for the Advancement of Science
1999-present Member American Society for Human Genetics
2000 Abstract selected for late breaking plenary session, ASHG annual meeting
2001 AIMM-ASBMR John Haddad Young Investigator Award

Publications:
1. S.L. Chissoe, Y.F.Wang, S.W. Clifton, N. Ma, H.J. Sun, J.S. Lobsinger, S.M. Kenton, J.D. White and B.A. Roe. Strategies for Rapid and Accurate DNA Sequencing. Methods: A Companion to Methods in Enzymology 3, 55-65 (1991).

2. H.Q. Pan, Y.P. Wang, S.L. Chissoe, A. Bodenteich, Z. Wang, K. Iyer, S.W. Clifton, J.S. Crabtree and B.A. Roe. The complete nucleotide sequences of the pSacBII P1 cloning vector and three cosmid cloning vectors: pTCF, svPHEP, and LAWRIST16. Genetic Analysis Techniques and Applications 11, 181-186 (1994).

3. S.L. Chissoe, A. Bodenteich, Y.F. Wang, Y.P. Wang, D. Burian, S.W. Clifton, J.S. Crabtree, A. Freeman, K.Iyer, L. Jian, Y.Ma, H.J. McLaury, H.Q. Pan, O.H. Sarhan, S. Toth, Z. Wang, G. Zhang, N. Heistercamp, J. Groffen, and B.A. Roe. Sequence and Analysis of the Human ABL Gene, the BCR Gene, and Regions Involved in the Philadelphia Chromosomal Translocation. Genomics 27, 67-82 (1995).

4. J. Ballard, J. Crabtree, B. A. Roe and R. K. Tweten. The primary structure of Clostridium septicum alpha toxin exhibits similarity with Aeromonas hydrophila aerolysin. Infect. Immun. 63, 340-344 (1995).

1. X. Wu, C.E. Robinson, H.W. Fong, J.S. Crabtree, B.R. Rodriguez, B.A. Roe and J.M. Gimble. Cloning and Characterization of the Murine Activin Receptor Like Kinase-1 (ALK-1) Homolog. Biochem. Biophys. Res. Commun. 216, 78-83 (1995)

2. B. Roe, J. Crabtree and A. Khan. DNA Isolation and Sequencing. John Wiley and Sons Ltd, New York, NY, 1996.

3. P. Manickam, S.C. Guru, L.V. Debelenko, S.K. Agarwal, S.E. Olufemi, J.M. Weismann, M.S. Boguski, J.S. Crabtree, Y. Wang, B.A. Roe, I.A. Lubensky, Z. Zhuang, M.B. Kester, A.L. Burns, A.S. Spiegel, S.J. Marx, L.A. Liotta, M.R. Emmert-Buck, F.S. Collins, S.C. Chandrasekharappa. Eighteen new polymorphic markers in the multiple endocrine neoplasia, type 1 (MEN1) region. Human Genetics 101(1):102-8(1997).

4. S.C. Guru, S.E. Olufemi, P. Manickam, C. Cummings, L.M. Gieser, B.L. Pike, M.L. Bittner, Y. Jiang, A.C. Chinault, N.J. Nowak, A. Brzozowska, J.S. Crabtree, Y. Wang, B.A. Roe, J.M. Weismann, M.S. Boguski, S.K. Agarwal, A.L. Burns, A.M. Spiegel, S.J. Marx, W.L. Flejter, P.J. deJong, F.S. Collins, S.C. Chandrasekharappa. A 2.8 Mb clone contig of the multiple endocrine neoplasia, type 1 (MEN1) region at 11q13. Genomics 42:436-445 (1997).

5. S.C. Chandrasekharappa, S.C. Guru, P. Manickam, S.E. Olufemi, F.S. Collins, M.R. Emmert-Buck, L.V. Debelenko, Z. Zhuang, I.A. Lubensky, L.A. Liotta, J.S. Crabtree, Y. Wang, B.A. Roe, J.Weismann, M.S. Boguski, S.K. Agarwal, M.B. Kester, Y.S. Kim, C. Heppner, Q. Dong, A.M. Spiegel, A.L. Burns, S.J. Marx. Positional Cloning of the Gene for Multiple Endocrine Neoplasia, type 1. Science 276:404-407 (1997).

6. S.C. Guru, S.K. Agarwal, P. Manickam, S.E. Olufemi, J.S. Crabtree, J.M. Weisemann, M.B. Kester, Y.S. Kim, Y. Wang, M.R. Emmert-Buck, L.A. Liotta, A.M. Spiegel, M.S. Boguski, B.A. Roe, F.S. Collins, S.J. Marx, L. Burns, and S.C. Chandrasekharappa. A transcript map for the 2.8 Mb region containing the multiple endocrine neoplasia type 1 locus. Genome Research 7(7):725-35 (1997).

7. Z. Zhuang, A.O. Vortmeyer, S. Pack, S. Huang, T.A. Pham, C. Wang, W.S. Park, S.K. Agarwal, L.V. Deblenko, M. Kester, S.C. Guru, P. Manickam, S.E. Olufemi, F. Yu, C. Heppner, J.S. Crabtree, M.C. Skarulis, D.J. Venzon, M.R. Emmert-Buck, A.M. Spiegel, S.C. Chandrasekharappa, F.S. Collins, A.L. Burns, S.J. Marx, I.A. Lubensky, et al. Somatic mutatations of the MEN1 tumor suppresor gene in sporadic gastrinomas and insulinomas. Cancer Research 57(21):4682-6 (1997).

8. Z. Zhuang, S.Z. Ezzat, A.O. Vortmeyer, R. Weil, E.H. Oldfield, W.S. Park, S. Pack, S. Huang, S.K. Agarwal, S.C. Guru, P. Manickam, L.V. Debelenko, M.B. Kester, S.E. Olufemi, C. Heppner, J.S. Crabtree, A.L. Burns, A.M. Spiegel, S.J. Marx, S.C. Chandrasekharappa, F.S. Collins, M.R. Emmert-Buck, L.A. Liotta, S.L. Asa, I.A. Lubensky. Mutations of the MEN1 tumor suppressor gene in pituitary tumors. Cancer Research 57(21):5446-51 (1997).

9. P. Manickam, S.C. Guru, L.V. Debelenko, S.K. Agarwal, S.E. Olufemi, J.M. Weismann, M.S. Boguski, J.S. Crabtree, Y. Wang, B.A.Roe, I.A. Lubensky, Z. Zhuang, M.B. Kester, A.L. Burns, A.M. Spiegel, S.J. Marx, L.A. Liotta, M.R. Emmert-Buck, F.S. Collins, and S. C. Chandrasekharappa. Eighteen new polymorphic markers in the multiple endocrine neoplasia type 1 (MEN1) region. Human Genetics 101(1):102-8 (1997).

10. L.V. Debelenko, E. Brambilla, S.K. Agarwal, J.I. Swalwell, M.B. Kester, I.A. Lubensky, Z. Zhuang, S.C. Guru, P. Manickam, S.E. Olufemi, S.C. Chandrasekharappa, J.S. Crabtree, Y.S. Kim, C. Heppner, A.L. Burns, A.M. Spiegel, S.J. Marx, L.A. Liotta, F.S. Collins, W.D. Travis, and M.R. Emmert-Buck. Identification of MEN1 gene mutations in sporadic carcinoid tumors of the lung. Human Molecular Genetics 6(13):2285-90 (1997).

11. S.J. Marx, S.K. Agarwal, M.B. Kester, Y.S. Kim, C. Heppner, A.M. Spiegel, A.L. Burns, M.R. Emmert-Buck, L.V. Debelenko, Z. Zhuang, I. Lubensky, L.A. Liotta, J.S. Crabtree, Y. Wang, B.A. Roe, J. Weismann, M.S. Boguski, J.L. Doppman, M.C. Skarulis, R.H. Alexander, S.C. Guru, P. Manickam, S.E. Olufemi, F.S. Collins and S.C. Chandrasekharappa. “Multiple Endocrine Neoplasia, Type 1: From Clinical Physiology to the Gene” in Parathyroid Diseases: From the Gene to the Cure. (edited by M.L. Brandi) SEE Editrice-Firenze, Firenze, 1997.

12. S.K. Agarwal, L.V. Debelenko, M.B. Kester, S.C. Guru, P. Manickam, S.E. Olufemi, M.C. Skarulis, C. Heppner, J.S. Crabtree, I.A. Lubensky, Z. Zhuang, Y.S. Kim, S.C. Chandrasekharappa, F.S. Collins, L.A. Liotta, A.M. Spiegel, A.L. Burns, M.R. Emmert-Buck, and S.J. Marx. Analysis of recurrent germline mutations int he MEN1 gene encountered in apparently unrelated families. Human Mutation 12(2):75-82 (1998).

13. S.C. Guru, P. Manickam, J.S. Crabtree, S.E. Olufemi, S.K. Agarwal and L.V. Debelenko. Identification and characterization of the multiple endocrine neoplasia type 1 (MEN1) gene. Journal of Internal Medicine 243(6):433-9 (1998).

14. S.J. Marx, S.K. Agarwal, M.B. Kester, C. Heppner, Y.S. Kim, M.C. Skarulis, L.A. James, P.K. Goldsmith, S.K. Saggar, S.Y. Park, A.M. Spiegel, A.L. Burns, L.V. Debelenko, Z. Zhuang, I.A. Lubensky, L.A. Liotta, M.R. Emmert-Buck, S.C. Guru, P. Manickam, J. Crabtree, M.R. Erdos, F.S. Collins, S.C. Chandrasekharappa. Multiple endocrine neoplasia, type 1: Clinical and genetic features of the hereditary endocrine neoplasias. Recent Progress in Hormone Research 54:397-438; discussion 438-9 (1999).

15. N. A. Akopyants, S. W. Clifton, D. Kersulyte, J.S. Crabtree, B. E. Youree, C. A. Reece, B. A. Roe and D. E. Berg. Analysis of the cag Pathogenicity Island of Helicobacter pylori. Molecular Microbiology 28: 37-53 (1998).

16. S.J. Marx, S.K. Agarwal, C. Heppner, Y.S. Kim, M.B. Kester, P.K. Goldsmith, M.C. Skarulis, A.M. Spiegel, A.L. Burns, L.V. Debelenko, Z.Zhuang, I.A. Lubensky, L.A. Liotta, M.R. Emmert-Buck, S.C. Guru, P. Manickam, J.S. Crabtree, F.S. Collins, and S.C. Chandrasekharappa. The Gene for Multiple Endocrine Neoplasia, Type 1: Recent Findings. Bone 25 (1):119-122 (1999).

17. S.C. Guru, J.S. Crabtree, K.D. Brown, K.J. Dunn, P. Manickam, N.B. Prasad, D. Wangsa, A.L. Burns, A.M.Spiegel, S.J. Marx, W.J. Pavan, F.S. Collins, S.C. Chandrasekharappa. Isolation, genomic organisation and expression analysis of Men1, the murine homolog of the MEN1 gene. Mammalian Genome 10(6):592-6 (1999).

18. I. Dunham, N. Shimizu, B.A. Roe, S. Chissoe, et al. The DNA Sequence of Human Chromosome 22. Nature 402:489-495 (1999).

19. The Genome International Sequencing Consortium. Initial sequencing and analysis of the human genome. Nature 409, 860-921 (2001). (See web site supplemental information for complete author listing).

20. J.S. Crabtree, P.C. Scacheri, J.M. Ward, L. Garrett-Beal, M.R.Emmert-Buck, K.A. Edgemon, D. Lorang, S.K. Libutti, S.C. Chandrasekharappa, S.J. Marx, A.M. Spiegel, and F.S. Collins. A mouse model of multiple endocrine neoplasia, type 1 develops multiple endocrine tumors. Proc.Natl. Acad. Sci, USA 98(3):1118-1123 (2001).

21. P.C. Scacheri*, J.S. Crabtree*, E.A. Novotny, L. Garrett-Beal, A. Chen, K.A. Edgemon, S.J. Marx, A.M. Spiegel, S.C. Chandrasekharappa and F.S. Collins. Bidirectional activity of PGK-neomycin and unexpected embryonic lethality in heterozygous chimeric knockout mice. Genesis 30:259-263 (2001).

22. K.E. Sukhodolets, A.B. Hickman, S.K. Agarwal, M.V. Sukhodolets, V.H. Obungu, E.A. Novotny, J.S. Crabtree, S.C. Chandrasekharappa, F.S. Collins, A.M. Spiegel, A.L. Burns, and S.J. Marx. The 32-kilodalton subunit of replication protein A interacts with menin, the product of the MEN1 tumor suppressor gene. Molecular and Cellular Biology 23(2):493-509 (2003).

23. S.K. Libutti, J.S. Crabtree, D. Lorang, A.L. Burns, C. Mazzanti, S. Hewitt, J.M. Ward, M. Emmert-Buck, A. Remaley, M. Miller, E. Turner, H.R. Alexander, A. Arnold, S.J. Marx, F.S. Collins and A.M. Spiegel. Parathyroid gland-specific deletion of the mouse Men1 gene results in parathyroid neoplasia and hypercalcemic hyperparathyroidism. Journal of Clinical Investigation submitted (2003).

24. J.S. Crabtree, P.C. Scacheri, J.M. Ward, S.R. McNally, G.P. Swain, J.H. Hager, D. Hanahan, H.Edlund, M.A. Magnuson, L.Garrett-Beal, A.L. Burns, S.C. Chandrasekharappa, S.J. Marx, A.M. Spiegel and F.S. Collins. Of Mice and MEN1: Insulinomas in a conditional mouse knockout. Molecular and Cellular Biology submitted (2003).

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